Azoles are typically used as antifungals. There are many types that are commonly used Clomatrizaole, Ketaconazole, Fluconazole, and many others. The problem starts because many fungi develop resistance to Azoles, and it is seen among many HIV infected individuals.
More and more drugs are commonly being developed to help fight Fungi that become resistant after people take antifungals for years. Similar to what antibiotics do, the fungus become more resistant and harder to fight off. According to the NIH, http://www.ncbi.nlm.nih.gov/pubmed/11815273 – “Development of azole resistance in fungi may occur through increased levels of the cellular target, upregulation of genes controlling drug efflux, alterations in sterol synthesis and decreased affinity of azoles for the cellular target. Here, we review the adaptative changes in fungi, in particular Candida albicans, in response to inhibitors of ergosterol biosynthesis.”
When Candida become Azole resistant, it becomes very difficult to treat. Sometimes doses of drugs are increased, or you use a different drug that it is most likely not resistant to. Whatever you do, do try to strengthen your immune system as much as possible. You want to at least try to fight the drug from the inside as well as from the outside.